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Biomimetic models in radiotherapy research: An essential bridge between bench and beam

Li, Nick; Jones, Christopher M; Rane, Jayant K; Tape, Christopher J; Hawkins, Maria A; (2025) Biomimetic models in radiotherapy research: An essential bridge between bench and beam. Cancer Cell 10.1016/j.ccell.2025.06.001. (In press).

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Abstract

Biomimetic in vitro models that more accurately replicate tumor and microenvironmental complexity are transforming radiotherapy research. Unlike traditional 2D cell lines, 3D models such as organoids and organ-on-chips capture key determinants of radiation sensitivity and resistance, improving translational relevance. Broader adoption of these systems promises to bridge the gap between laboratory research and clinical radiotherapy, enabling more effective biomarker discovery and therapeutic innovation.

Type: Article
Title: Biomimetic models in radiotherapy research: An essential bridge between bench and beam
Location: United States
DOI: 10.1016/j.ccell.2025.06.001
Publisher version: https://doi.org/10.1016/j.ccell.2025.06.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10211113
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