Davidson, Joseph R;
Mutanen, Annika;
Granström, Anna Löf;
Hoel, Anders Telle;
Loukogeorgakis, Stavros P;
De Coppi, Paolo;
Bjørnland, Kristin;
... Curry, Joe; + view all
(2025)
Impaired Fertility and Sexual Function in Women With Hirschsprung Disease: Results From an International Multi‐Centre Cross‐Sectional Study.
BJOG: An International Journal of Obstetrics & Gynaecology
10.1111/1471-0528.18294.
(In press).
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Abstract
OBJECTIVE: Hirschsprung is a congenital disorder affecting the gastrointestinal tract. However, pelvic colorectal surgery in infancy has been hypothesised to impact gynaecological outcomes in later life. Describe sexual function and fertility outcomes in women with Hirschsprung disease compared to population controls. Assess factors associated with poor outcomes (sexual dysfunction and subfertility). DESIGN: International multicentre cross-sectional cohort study with comparison to controls from the general population. SETTING: Status post-discharge from paediatric services. POPULATION: Female patients aged > 20 years. METHODS: Validated questionnaire-based survey with linkage to patient medical records. Comparison with controls using univariate analyses. MAIN OUTCOME MEASURES: Sexual dysfunction (Female Sexual Function Index; FSFI ≤ 26), Subfertility at 1 and 2 years. RESULTS: Sexual dysfunction as per the FSFI was more common in patients and associated with poor functional outcomes; sexual abstinence seemed to associate even more so with poor bowel outcomes. Subfertility was higher in patients compared to controls (1 year: 21/45 (47%) vs. 38/178 (21%), p = 0.0008; 2 years: 12/45 (27%) vs. 17/178 (10%), p = 0.004). There was an increased proportion of patients who had accessed fertility services (20/45 (44%) vs. 43/178 (24%); p = 0.009), the proportion of successful pregnancies in patients attempting to conceive with IVF (11/17 (65%) vs. 27/43 (63%); p = 1.0) was similar. CONCLUSIONS: These novel data suggest that women with Hirschsprung disease who have undergone reconstructive surgery may be at risk for adverse sexual function and fertility outcomes.
| Type: | Article |
|---|---|
| Title: | Impaired Fertility and Sexual Function in Women With Hirschsprung Disease: Results From an International Multi‐Centre Cross‐Sectional Study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/1471-0528.18294 |
| Publisher version: | https://doi.org/10.1111/1471-0528.18294 |
| Language: | English |
| Additional information: | © 2025 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Bowel incontinence, congenital colorectal disease, fertility outcomes, FSFI, Hirschsprung disease, HSCR, sexual function, subfertility |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10211063 |
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