Alhamdi, Alaa A;
Mackie, Shona;
Trueman, Ryan P;
Rayner, Melissa LD;
(2025)
Pharmacologically targeting Schwann cells to improve regeneration following nerve damage.
Frontiers in Cell and Developmental Biology
, 13
, Article 1603752. 10.3389/fcell.2025.1603752.
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Abstract
Schwann cells provide essential support for nerve growth and survival following peripheral nerve damage by producing various growth factors and other signalling molecules. Modulating the proliferation, differentiation, migration, or myelination of Schwann cells could result in accelerated repair and regeneration of injured nerves, ultimately leading to improved motor and sensory function. Therefore, Schwann cells are commonly advocated as therapeutic targets for nerve damage, which could be mediated by pharmacological intervention. This review discusses how compounds such as growth factors, hormones, and small molecules can regulate intracellular signalling pathways involved in modulating Schwann cells.
| Type: | Article |
|---|---|
| Title: | Pharmacologically targeting Schwann cells to improve regeneration following nerve damage |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fcell.2025.1603752 |
| Publisher version: | http://dx.doi.org/10.3389/fcell.2025.1603752 |
| Language: | English |
| Additional information: | Copyright © 2025 Alhamdi, Mackie, Trueman and Rayner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Schwann cells, cell phenotype, nerve regeneration, pharmacological intervention, signalling pathway |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10210986 |
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