Morandotti, Cecilia;
Rigny, Louise;
Williams, Thomas B;
Badariotti, Juan I;
Miller‐Dicks, Matt;
Bhogal, Amar S;
Han, Shachula;
... Mani, Ali R; + view all
(2025)
Non‐invasive assessment of integrated cardiorespiratory network dynamics after physiological stress in humans.
The Journal of Physiology
, Article JP288939. 10.1113/jp288939.
(In press).
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Abstract
Visualizing the exchange of information between different components of the cardiorespiratory system is essential for understanding physiological control and is valuable for monitoring individuals in various clinical settings and extreme environments. Network physiology is a multidisciplinary field that explores the collective behaviour of physiological systems, offering a novel approach to understanding these complex interactions. The present study aimed to develop a non‐invasive method to visualize the cardiorespiratory network under control conditions and after isolated or combined exposure to hypoxia, exercise and sleep‐deprivation (total or partial). Using transfer entropy, a measure of causal relationships between time‐series data, network maps were generated to illustrate information flow between 10 min parallel cardiorespiratory signals, namely, heart rate, respiratory rate, minute ventilation, tidal volume, capillary oxygen saturation (), end‐tidal O2 and end‐tidal CO2 concentrations. Twenty‐two healthy participants underwent assessments at rest and following normobaric hypoxia (: 0.12), moderate intensity cycling (100 W) and overnight sleep‐deprivation both in isolation and in combination. The results showed that each stressor generated a distinct pattern of physiological information exchange. Increased connectivity within the networks was observed during exercise alone or when combined with other stressors. During exercise, heart rate emerged as the primary recipient of information, whereas SpO₂ served as the main disseminator. Hypoxia led to the engagement of as a hub in the network. Sleep‐deprivation was associated with a shift in the flow of information between the nodes during hypoxia. This non‐invasive approach effectively maps cardiorespiratory interactions, offering potential for assessing integrated network dynamics in health and disease.
| Type: | Article |
|---|---|
| Title: | Non‐invasive assessment of integrated cardiorespiratory network dynamics after physiological stress in humans |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1113/jp288939 |
| Publisher version: | https://doi.org/10.1113/jp288939 |
| Language: | English |
| Additional information: | © 2025 The Author(s). The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | exercise physiology, extreme environment, hypoxia network physiology, sleep-deprivation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10210923 |
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