Zhang, Changze;
Zhao, Guangchun;
Wang, Xiaorui;
Li, Mengting;
Li, Zhengmao;
E, Yixun;
Cao, Xiaxin;
... Liu, Chaozong; + view all
(2025)
Imperfect hydroxyapatite bioceramics derived from golden pomfret have enhanced osteogenic properties.
Scientific Reports
, 15
, Article 20582. 10.1038/s41598-025-06015-8.
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Abstract
Imperfect hydroxyapatite (IHA) bioceramics, which contain defects such as calcium deficiency, carbonate substitution, and metal cation substitution, exhibit improved osteogenic properties. In this study, we used a two-step calcination-hydrothermal process to manufacture two types of golden pomfret bone-derived imperfect hydroxyapatite bioceramics (G-IHA): carbonated calcium-deficient hydroxyapatite (CD-IHA) and carbonated hydroxyapatite (C-IHA). Their composition, surface morphology, zeta potential, degradation capacity, mineralization and osteogenic properties were systematically investigated. The results revealed that G-IHA with a higher defect content, including A-type carbonate substitution and Ca vacancies, had negatively charged surface. As a result, G-IHA surfaces are more favourable to ion exchange and interaction with cations (e.g., Na+, Ca2+) in the microenvironment, which results in improved degradation and mineralization. Specifically, after 28 days of degradation, G-IHA showed significantly higher weight losses (CD-IHA and C-IHA were 17% and 13%, respectively) than commercial hydroxyapatite (CHA; 7%). In addition, G-IHA have a higher better bone-like apatite formation ability, and a higher degree of osteogenic differentiation than CHA. Notably, carbonated calcium-deficient imperfect hydroxyapatite (CD-IHA) exhibited the highest bioactivity and osteogenic capacity as evidenced by its increased alkaline phosphatase activity and improved bone matrix mineralization capacity. In conclusion, this study revealed that imperfect hydroxyapatite bioceramics derived from golden pomfret bone have the potential to enhance osteogenic properties and be employed in clinical settings as bone substitute materials.
| Type: | Article |
|---|---|
| Title: | Imperfect hydroxyapatite bioceramics derived from golden pomfret have enhanced osteogenic properties |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-025-06015-8 |
| Publisher version: | https://doi.org/10.1038/s41598-025-06015-8 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Calcium-deficient hydroxyapatite, Carbonate substitution hydroxyapatite, Cation exchange, Enhanced osteogenic property, Golden pomfret bone |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10210824 |
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