Hameed, M;
De Kock, I;
Stoker, J;
Taylor, SA;
(2025)
ESR Essentials: diagnosis and assessment of treatment response in patients with luminal Crohn's disease—practice recommendations by the European Society of Gastrointestinal and Abdominal Radiology.
European Radiology
10.1007/s00330-025-11620-2.
(In press).
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Abstract
The European Society of Gastrointestinal and Abdominal Radiology (ESGAR) presents an ESR Essentials review article on Crohn’s disease (CD) diagnosis and treatment response assessment. The focus is on luminal disease, particularly in the small bowel, and to a lesser degree, the colon. Magnetic Resonance Enterography (MRE) and ultrasound are typically the first-line radiological investigations for known or suspected luminal CD. They are accurate for assessing the entirety of the bowel wall and extra-enteric tissues and are generally well tolerated by patients. CT has utility as well, especially in the acute setting. Disease location, extent, and phenotype should be assessed. Well-validated imaging signs of acute inflammation (active disease) are responsive to therapeutic interventions and include bowel mural thickening and oedema, perimural inflammation, ulceration, and hypervascularity. Other phenotypes (stricturing or penetrating with fistulae and/or abscesses) can coexist, and the predominant disease phenotype should be established. We recommend that radiologists work closely within multidisciplinary teams to optimise imaging selection for individual patients, tailored to the clinical question. Findings should be clearly communicated to best inform management decisions using standardised terminology, and structured reporting of disease status, treatment response categorisation, and any associated complications.
| Type: | Article |
|---|---|
| Title: | ESR Essentials: diagnosis and assessment of treatment response in patients with luminal Crohn's disease—practice recommendations by the European Society of Gastrointestinal and Abdominal Radiology |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00330-025-11620-2 |
| Publisher version: | https://doi.org/10.1007/s00330-025-11620-2 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Crohn’s disease; Magnetic resonance imaging; Ultrasound; Intestine, Small bowel |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10210659 |
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