Fang, Le;
Ai, Rui;
Sandoval-Salinas, Maria Eugenia;
Tan, Lei;
Liu, Chun;
Wen, Qiang;
Tang, Huarong;
... Fang, Xiaohong; + view all
(2025)
Carbazole Engineering in D-A-D Molecules to Improve the NIR-II Performance for Tumor Micrometastasis Imaging.
Nano Letters
, 25
(23)
pp. 9433-9440.
10.1021/acs.nanolett.5c02001.
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Abstract
It is important to image tumor micrometastases in fluorescence-guided surgery (FGS), which requires highly emissive materials with a high signal-to-background ratio. As one type of bright NIR-II dye, donor-acceptor-donor (D-A-D) molecules have been widely applied for in vivo imaging. However, the brightness of D-A-D molecules when encapsulated in nanoparticles for bioimaging is often unsatisfactory due to aggregation-caused quenching or a decrease in absorption. In this study, we introduced carbazole groups in the D-A-D molecules, which resulted in a reduction of fluorescence quenching in the aggregated state due to the larger intermolecular distance. Through proper engineering of the carbazole groups, the emission spectra of the nanoparticles could be red-shifted with a peak beyond 1000 nm, while maintaining strong absorption and high quantum yield. The brightest TBTC-4 nanoparticles were successfully applied for tumor micrometastasis imaging in mice, with metastases as small as 0.5 mm diameter, which demonstrates their promising clinical application in FGS.
| Type: | Article |
|---|---|
| Title: | Carbazole Engineering in D-A-D Molecules to Improve the NIR-II Performance for Tumor Micrometastasis Imaging |
| Location: | United States |
| DOI: | 10.1021/acs.nanolett.5c02001 |
| Publisher version: | https://doi.org/10.1021/acs.nanolett.5c02001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | NIR-II imaging, tumor micrometastasis, D−A−D molecules, carbazole derivatives |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10210373 |
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