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Post-Esophagectomy Dumping Syndrome: Assessing Quality of Life of Long-Term Survivors

Dellaportas, D; Margaris, I; Tsalavoutas, E; Gkiafi, Z; Pikouli, A; Myoteri, D; Pararas, N; ... Pikoulis, E; + view all (2025) Post-Esophagectomy Dumping Syndrome: Assessing Quality of Life of Long-Term Survivors. Journal of Clinical Medicine , 14 (10) p. 3587. 10.3390/jcm14103587. Green open access

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Abstract

Background/Objectives: Survival rates for esophageal cancer patients have markedly improved. Inevitably, attention has been drawn to functional and quality-of-life problems. The aim of the current study was to investigate the prevalence of dumping syndrome in patients following esophageal resection and its correlation with postoperative quality of life. Methods: This cross-sectional study involved disease-free patients who underwent a potentially curative resection for esophageal or gastroesophageal junction carcinoma between January 2019 and January 2024 in a single academic institution. Patients were asked to fill in two questionnaires: the Dumping Syndrome Rating Scale (DSRS) and the QLQ-OG25. A Composite Dumping Syndrome Index (CDSI) was calculated by adding the summary severity and frequency scores for each patient. Results: During the study period, 42 patients underwent esophagectomy for malignant esophageal or junctional tumors. In total, 14 eligible patients responded to the questionnaires at a mean time of 19.7 (±20.8) months following their operation. Three patients (21%) reported having at least quite severe problems related to at least two dumping symptoms. Six patients (43%) reported that they avoid certain foods in order to alleviate related problems. A high CDSI score was associated with significantly increased OG25 scores for dysphagia, eating restriction, odynophagia, pain and discomfort, and reflux (p < 0.05). Conclusions: Early dumping syndrome can occur in a significant proportion of patients following esophagectomy and may adversely affect quality of life.

Type: Article
Title: Post-Esophagectomy Dumping Syndrome: Assessing Quality of Life of Long-Term Survivors
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/jcm14103587
Publisher version: https://doi.org/10.3390/jcm14103587
Language: English
Additional information: Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Keywords: dumping syndrome, esophagectomy, quality of life
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10210187
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