UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Neighboring Cells as Living Substrates for Guiding Collective Cell Migration during Development

Le, Hoang Anh; (2025) Neighboring Cells as Living Substrates for Guiding Collective Cell Migration during Development. Cold Spring Harbor Perspectives in Biology , 17 (6) , Article a041741. 10.1101/cshperspect.a041741. Green open access

[thumbnail of Le_Neighboring Cells as Living Substrates for Guiding Collective Cell Migration during Development.pdf]
Preview
Text
Le_Neighboring Cells as Living Substrates for Guiding Collective Cell Migration during Development.pdf - Accepted Version

Download (1MB) | Preview

Abstract

As cells migrate inside the body, they encounter various biochemical and physical cues that provide them with directional guidance. In the past 20 years or so, there has been a significant shift in the effort to understand how physical factors contribute to cellular behaviors. Nevertheless, much of the research has been focused on the interactions between migrating cells and the extracellular matrix in vitro as these are simpler and more accessible models, while neglecting the importance of the cellular environment, which often requires in vivo model systems. With the development of new technology along with the appropriate choice of model organisms, the interesting topic of cell-on-cell interaction during migration is beginning to unravel. In this review, we will take a deep dive into some of the recent results that demonstrate how the biophysics of the cellular environment can impact cell migration, with a strong focus on the use of in vivo model systems, naming the Drosophila border cells, the Xenopus cephalic neural crest, and the zebrafish posterior lateral line primordium.

Type: Article
Title: Neighboring Cells as Living Substrates for Guiding Collective Cell Migration during Development
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1101/cshperspect.a041741
Publisher version: https://doi.org/10.1101/cshperspect.a041741
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10209829
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item