Assassi, Shervin;
Denton, Christopher P;
Zwick, Matthias;
Schmid, Ramona;
Ittrich, Carina;
Litzenburger, Tobias;
Visvanathan, Sudha;
(2025)
Peripheral blood gene expression profiling shows prognostic significance for the course of interstitial lung disease in systemic sclerosis.
Arthritis & Rheumatology
10.1002/art.43262.
(In press).
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Abstract
Objective: We used data from the placebo arm of the SENSCIS trial to determine the prognostic/predictive significance of peripheral blood cell (PBC) transcript modules for the course of forced vital capacity (FVC) in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) with and without mycophenolate mofetil (MMF) treatment. /./ Methods: Patients had SSc-ILD with first non-Raynaud symptom within ≤7 years. MMF treatment was permitted if taken at a stable dose for ≥6 months. PBC RNA samples were taken at baseline. Global RNA sequencing was performed, followed by a modular analysis using 62 curated whole blood modules. The prognostic significance of baseline composite modular scores for decline in FVC % predicted at week 52 was analyzed using mixed models for repeated measures. /./ Results: Among patients taking MMF (n=120), higher baseline lymphoid lineage and mitochondrial/protein synthesis modules were associated with a better course of FVC % predicted, while higher baseline myeloid lineage and inflammation modules were associated with a faster decline in FVC % predicted. Among patients not taking MMF (n=118), only myeloid lineage and inflammation modules were associated with a faster decline in FVC % predicted. /./ Conclusion: Among patients with SSc-ILD in the SENSCIS trial, PBC modules involved in myeloid lineage were associated with a faster decline in FVC regardless of MMF treatment. Higher baseline lymphoid, protein synthesis and mitochondrial module scores were associated with a better course of SSc-ILD among patients on MMF treatment. Blood gene expression profiles might be useful prognostic/predictive biomarkers in patients with SSc-ILD.
| Type: | Article |
|---|---|
| Title: | Peripheral blood gene expression profiling shows prognostic significance for the course of interstitial lung disease in systemic sclerosis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/art.43262 |
| Publisher version: | https://doi.org/10.1002/art.43262 |
| Language: | English |
| Additional information: | Copyright © 2025 The Author(s). This is an open access article under the terms of the Creative Commons Attribution-Non Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Keywords: | pulmonary fibrosis; rheumatic diseases |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10209181 |
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