Sarama, Roudin;
Matharu, Priya K;
Abduldaiem, Yousef;
Correa, Mab P;
Gil, Cristiane D;
Greco, Karin V;
(2022)
In Vitro Disease Models for Understanding Psoriasis and Atopic Dermatitis.
Frontiers in Bioengineering and Biotechnology
, 10
, Article 803218. 10.3389/fbioe.2022.803218.
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Abstract
Psoriasis (PS) and Atopic Dermatitis (AD) are two of the most prevalent inflammatory skin diseases. Dysregulations in the immune response are believed to play a crucial role in the pathogenesis of these conditions. Various parallels can be drawn between the two disorders, as they are both genetically mediated, and characterised by dry, scaly skin caused by abnormal proliferation of epidermal keratinocytes. The use of in vitro disease models has become an increasingly popular method to study PS and AD due to the high reproducibility and accuracy in recapitulating the pathogenesis of these conditions. However, due to the extensive range of in vitro models available and the majority of these being at early stages of production, areas of development are needed. This review summarises the key features of PS and AD, the different types of in vitro models available to study their pathophysiology and evaluating their efficacy in addition to discussing future research opportunities.
| Type: | Article |
|---|---|
| Title: | In Vitro Disease Models for Understanding Psoriasis and Atopic Dermatitis |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fbioe.2022.803218 |
| Publisher version: | https://doi.org/10.3389/fbioe.2022.803218 |
| Language: | English |
| Additional information: | © 2022 Sarama, Matharu, Abduldaiem, Corrêa, Gil and Greco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | psoriais, keratinocyte, fibroblast, in vitro, 3D models, atopic dermatitis (AD) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10209048 |
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