Belgers, Vera;
Van Genderen, Maisa NG;
De Schotten, Michel Thiebaut;
Cakmak, Marcus;
Douw, Linda;
Ferles, Alexandros;
Barkhof, Frederik;
... De Witt Hamer, Philip C; + view all
(2025)
Impact of resection location on depressive symptoms following glioma surgery.
Neuro-Oncology Advances
, 7
(1)
, Article vdae222. 10.1093/noajnl/vdae222.
Preview |
Text
Impact of resection location on depressive symptoms following glioma surgery.pdf - Published Version Download (793kB) | Preview |
Abstract
Background: Glioma surgery aims to maximize tumor removal while preserving functional integrity. Functional outcome usually focuses on neurological and neurocognitive functions, but surgery may also affect mood regulation. We determined the occurrence of depressive symptoms after surgery and investigated associated factors, including preoperative depressive symptoms and the location of the resection. // Methods: We included a single-center retrospective cohort of patients with supratentorial diffuse glioma (WHO grade 2–4) who underwent first-time surgical resection between 2009 and 2021 and who completed the Center for Epidemiologic Studies Depression Scale (CES-D) before and one year after surgery. Resection cavities were segmented on postoperative MRI scans. White matter disconnections were computed, the so-called disconnectome, to examine distant effects. Multivariable regression analysis was used to relate patient, tumor, and treatment characteristics to postoperative depression scores and changes after surgery. Lesion-symptom mapping was used to relate resection and disconnectome locations to these scores and changes. // Results: The study included 83 patients. Before surgery, 25% of patients had depressive symptoms and one year after surgery 34%, which was not statistically different. Resections of gliomas in the right hemisphere were significantly associated with increased depression scores after surgery. A resection involving the left anterior temporal region was significantly associated with low postoperative depression scores. Disconnectome locations were not associated with either postoperative or change in depression scores. // Conclusions: Resection locations affect depressive symptoms in glioma patients. This information may be useful for patient counseling.
| Type: | Article |
|---|---|
| Title: | Impact of resection location on depressive symptoms following glioma surgery |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/noajnl/vdae222 |
| Publisher version: | https://doi.org/10.1093/noajnl/vdae222 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2024. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. |
| Keywords: | Brain neoplasms, connectome, depression, Lesion-symptom mapping, mood disorders |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10208999 |
Archive Staff Only
 |
View Item |
