Lioliou, G; Charman, A; Roche i Morgó, O; Astolfo, A; Cipiccia, S; Endrizzi, M; Munro, PRT; ... Hagen, CK; + view all Lioliou, G; Charman, A; Roche i Morgó, O; Astolfo, A; Cipiccia, S; Endrizzi, M; Munro, PRT; Bate, D; Olivo, A; Hagen, CK; - view fewer (2023) X-ray phase contrast CT with an amplitude modulated beam: moving towards clinical use. In: Proceedings of the 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD). IEEE: Vancouver, Canada.

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Abstract

X-ray phase contrast (XPC) computed tomography (CT) provides access to an increased contrast for weakly attenuating samples, opening new application pathways. We have developed an XPC-CT approach based on amplitude modulation of the beam, achieved by using a mask with alternating absorbing septa and transmitting apertures placed immediately upstream of the scanned sample. Our approach can be implemented with two distinct sensing mechanisms: beamtracking and edge illumination, applicable to different imaging scenarios and experimental constraints. Both are compatible with "single-frame" retrieval approaches, thereby enabling fast scans in which the sample is continuously rotated (flyscans). Our group has dedicated the best part of the last decade to developing the technique(s), and more recently has explored their potential clinical use in two applications (the real-time intra-operative scanning of excised breast and esophageal tissue). Here we provide an outlook on how recent technological advances, namely cycloidal and cycloidal-spiral CT, could further improve the method’s performance, especially in terms of meeting clinical constraints on scan time.

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