Pons, Maria Isabel;
Olivares, Andy L;
Mill, Jordi;
Matos, Jose Novo;
Garcia-Canadilla, Patricia;
Cerrada, Inma;
Guy, Anna;
... Camara, Oscar; + view all
(2025)
Cardiomyopathy and thrombogenesis in cats through left atrial morphological and fluid dynamics analysis.
Scientific Reports
, 15
, Article 12263. 10.1038/s41598-025-96245-7.
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Abstract
The relationship between atrial fibrillation (AF), blood flow disturbances and thrombus formation is well-established in humans. Thrombi primarily form in the left atrial appendage (LAA), but the specific role of LAA morphology remains unclear. Felines, despite rarely experiencing AF, present a valuable model for studying human heart diseases. Cats exhibit a high incidence of cardiomyopathies, often accompanied by significant left atrial dilation and thrombus formation. This unique aspect prompts research focusing on LAA morphology and function in relation to thrombus development. Our study, using advanced image processing and fluid simulations on 24 cat hearts ranging from normal to cardiomyopathy subjects, aims to find distinctions in left atrium (LA) and LAA morphologies, blood flow patterns and their relation to thrombus formation. Significantly different variables in feline heart groups included: heart weight, LAA volume, LA volume, ostium area, ostium area-to-heart weight ratio, centreline length and velocity at the LAA ostium. Fluid simulations revealed lower LAA blood flow velocities and increased thrombotic risk in cases with thrombi. Our study enhances the understanding of LAA structure and function, offering insights into thrombus formation mechanisms with potential implications for better managing thrombosis risk in patients.
| Type: | Article |
|---|---|
| Title: | Cardiomyopathy and thrombogenesis in cats through left atrial morphological and fluid dynamics analysis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-025-96245-7 |
| Publisher version: | https://doi.org/10.1038/s41598-025-96245-7 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10208609 |
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