Tavelli, A;
Vergori, A;
Cingolani, A;
Bai, F;
Azzini, AM;
Hara, GL;
Caponcello, MG;
... Cataudella, S; + view all
(2025)
ORCHESTRA Delphi consensus: clinical management of SARS-CoV-2 infection in people with HIV.
Clinical Microbiology and Infection
10.1016/j.cmi.2025.03.006.
(In press).
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Abstract
Objectives: The interaction between HIV and COVID-19 resulted in a syndemic that showed an excess burden of disease for people with HIV (PWH). Four years of the COVID-19 pandemic have raised many unsolved questions about the optimal care of COVID-19 in PWH. Methods: We performed a study using a three-round Delphi methodology involving a panel of physicians with expertise in HIV and COVID-19 infections. The main aim of the study was to provide recommendations on critical clinical issues of COVID-19 among PWH and to inform physicians and policy-makers for improving care and prevention of COVID-19 in PWH. A total of 27 questions were conceived, focusing on four main areas of interest in the management of COVID-19 in PWH; a panel of 34 experts in HIV and COVID-19 care expressed their level of agreement on each item. Questions that received agreement/disagreement ≥79.4% of panellists were identified and statements were generated accordingly. Results: Consensus was reached on 19/27 items, resulting in 18 final statements. These statements addressed: (a) risk of COVID-19 progression to severe disease among PWH; (b) COVID-19 diagnostics and laboratory procedures; (c) early treatments with antivirals and/or monoclonal antibodies; (d) use of corticosteroids; (e) COVID-19 preventive strategies. Discussion: This consensus's study guides infectious diseases physicians in making decisions regarding the care of PWH for COVID-19, where results from the scientific literature are limited or conflicting.
| Type: | Article |
|---|---|
| Title: | ORCHESTRA Delphi consensus: clinical management of SARS-CoV-2 infection in people with HIV |
| Location: | England |
| DOI: | 10.1016/j.cmi.2025.03.006 |
| Publisher version: | https://doi.org/10.1016/j.cmi.2025.03.006 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | COVID-19, Consensus, Delphi, HIV, SARS-CoV-2 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10208588 |
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