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Scarring and Skin Fibrosis Reversal with Regenerative Surgery and Stem Cell Therapy

Almadori, Aurora; Butler, Peter EM; (2024) Scarring and Skin Fibrosis Reversal with Regenerative Surgery and Stem Cell Therapy. Cells , 13 (5) , Article 443. 10.3390/cells13050443. Green open access

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Abstract

Skin scarring and fibrosis affect millions of people worldwide, representing a serious clinical problem causing physical and psychological challenges for patients. Stem cell therapy and regenerative surgery represent a new area of treatment focused on promoting the body’s natural ability to repair damaged tissue. Adipose-derived stem cells (ASCs) represent an optimal choice for practical regenerative medicine due to their abundance, autologous tissue origin, non-immunogenicity, and ease of access with minimal morbidity for patients. This review of the literature explores the current body of evidence around the use of ASCs-based regenerative strategies for the treatment of scarring and skin fibrosis, exploring the different surgical approaches and their application in multiple fibrotic skin conditions. Human, animal, and in vitro studies demonstrate that ASCs present potentialities in modifying scar tissue and fibrosis by suppressing extracellular matrix (ECM) synthesis and promoting the degradation of their constituents. Through softening skin fibrosis, function and overall quality of life may be considerably enhanced in different patient cohorts presenting with scar-related symptoms. The use of stem cell therapies for skin scar repair and regeneration represents a paradigm shift, offering potential alternative therapeutic avenues for fibrosis, a condition that currently lacks a cure.

Type: Article
Title: Scarring and Skin Fibrosis Reversal with Regenerative Surgery and Stem Cell Therapy
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/cells13050443
Publisher version: https://doi.org/10.3390/cells13050443
Language: English
Additional information: Copyright © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: Cell therapy; regenerative medicine; regenerative surgery; adipose stem cells; stromal vascular fraction; extracellular matrix; fat grafting; lipofilling; lipotransfer; fibrosis; scar
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10208582
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