Orlandi, Marco;
Masi, Stefano;
Lucenteforte, Ersilia;
Bhowruth, Devina;
Malanima, Marco A;
Darbar, Ulpee;
Patel, Kalpesh;
... D'Aiuto, Francesco; + view all
(2025)
Periodontitis treatment and progression
of carotid intima-media thickness:
a randomized trial.
European Heart Journal
, Article ehaf555. 10.1093/eurheartj/ehaf555.
(In press).
Preview |
Text
Chiesa_ehaf555.pdf Download (6MB) | Preview |
Abstract
Background and Aims: Intensive periodontal treatment (IPT) improves endothelial function in patients with periodontitis (PD). However, whether these changes can slow the progression of structural vascular remodelling remains unclear. This randomized clinical trial evaluated the impact of IPT on carotid intima-media thickness (cIMT) over 2 years (NCT03072342). Flow-mediated dilatation (FMD), blood pressure and pulse wave velocity (PWV) were assessed as secondary outcomes, while markers of inflammation, oxidative stress, and metabolomics were explanatory outcomes. // Methods: 135 consecutive, otherwise healthy participants with PD, were enrolled in a single-blind, single-centre, controlled trial, and randomized to IPT (n = 68; including scaling, root planning, and, when appropriate, surgical corrective therapy) or control periodontal treatment (CPT, n = 67; including supra-gingival scaling and polishing). cIMT was assessed at baseline, 12 and 24 months post-therapy. Blood pressure, FMD, PWV, markers of inflammation, oxidative stress, and metabolomics were assessed at baseline and at 2, 6, 12, 18, and 24 months post-intervention. // Results: After 24 months, cIMT was lower in the IPT vs the CPT group (−0.023 mm, 95% confidence interval −0.030.019 to −0.0227, P < 0.0001). FMD improved within 2 months in the IPT group and remained consistently higher than the CPT group throughout the study (P < 0.0001) correlating with the improved periodontal measurements at the same time points. No substantial differences were observed between groups in adverse events, anthropometric, blood pressure, PWV, or metabolomic markers. Among inflammatory and oxidative stress markers, glycoprotein acetyl was reduced in IPT compared with the CPT group participants (P < 0.05). // Conclusions: IPT led to favourable structural changes in the vascular phenotype, underscoring the impact of PD on cardiovascular health and further highlighting the potential role of treating PD to improve cardiovascular outcomes.
| Type: | Article |
|---|---|
| Title: | Periodontitis treatment and progression of carotid intima-media thickness: a randomized trial |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/eurheartj/ehaf555 |
| Publisher version: | https://doi.org/10.1093/eurheartj/ehaf555 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Periodontitis, Intima-media thickness, Endothelial function, Inflammation, Metabolomic |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10208298 |
Archive Staff Only
 |
View Item |
