Fatima, Roshan;
Akhade, Vijay Suresh;
Pal, Debosree;
Rao, Satyanarayana MR;
(2015)
Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets.
Molecular and Cellular Therapies
, 3
, Article 5. 10.1186/s40591-015-0042-6.
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Abstract
Long noncoding RNAs are emerging as key players in various fundamental biological processes. We highlight the varied molecular mechanisms by which lncRNAs modulate gene expression in diverse cellular contexts and their role in early mammalian development in this review. Furthermore, it is being increasingly recognized that altered expression of lncRNAs is specifically associated with tumorigenesis, tumor progression and metastasis. We discuss various lncRNAs implicated in different cancer types with a focus on their clinical applications as potential biomarkers and therapeutic targets in the pathology of diverse cancers.
| Type: | Article |
|---|---|
| Title: | Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets |
| Location: | Denmark |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s40591-015-0042-6 |
| Publisher version: | https://doi.org/10.1186/s40591-015-0042-6 |
| Language: | English |
| Additional information: | Copyright © 2015 Fatima et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| Keywords: | LncRNA; Development; Cancer; Biomarker; Therapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10208292 |
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