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The predictive power of autobiographical memory in shaping the mental health of young people: An individual participant data meta-analysis

Doan, Uyen; Hong, Dou; Mares, Leo; Butler, Molly; Askelund, Adrian Dahl; Gutenbrunner, Charlotte; Hiller, Rachel; ... Hitchcock, Caitlin; + view all (2025) The predictive power of autobiographical memory in shaping the mental health of young people: An individual participant data meta-analysis. Psychological Bulletin , 151 (4) pp. 455-475. 10.1037/bul0000474. Green open access

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Abstract

Reduced autobiographical memory (AM) specificity, characterized by difficulty recalling specific past events, is a feature of multiple psychiatric disorders. While meta-analyses indicate that reduced AM specificity can predict future symptom severity, its role as a premorbid risk factor for mental illness onset in young people remains unclear. Our preregistered individual participant data meta-analysis (PROSPERO; CRD42022287786) synthesized longitudinal data from 14 community-based studies of children and adolescents (N = 9,165). Most studies reported symptom severity (92.9%), with one third also reporting diagnostic status (35.7%). Assessment timing ranged from 2 months to 8.3 years following the autobiographical memory task. Multivariate mixed-effect models found no support for AM specificity predicting future symptom severity in depression or posttraumatic stress disorder. Contrary to expectations, higher memory specificity significantly predicted higher anxiety symptoms, but the quality of evidence was low. Intriguingly, reduced AM specificity significantly predicted an increased risk of receiving a psychiatric diagnosis and an earlier onset of disorder (hazard ratio = 0.55, p = .018). This risk was most robust for depressive disorders (hazard ratio = 0.21, p < .001). Findings suggest reduced AM specificity could be a risk factor for the onset of functionally impairing psychiatric disorders, but it does not consistently predict elevated symptoms in community-based samples. Further theoretical development is needed. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Type: Article
Title: The predictive power of autobiographical memory in shaping the mental health of young people: An individual participant data meta-analysis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1037/bul0000474
Publisher version: https://doi.org/10.1037/bul0000474
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: overgeneral memory; memory specificity; risk factor; depression; anxiety; eating disorders; individual participant data meta-analysis; ALSPAC
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10208259
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