Loke, Justin;
Upasani, Vinit;
Gaskell, Charlotte;
Fox, Sonia;
Fletcher, Rachel;
Thomas, Catherine;
Hopkins, Louise;
... Lowe, David M; + view all
(2023)
Defective T-cell response to COVID-19 vaccination in acute myeloid leukaemia and myelodysplastic syndromes.
British Journal of Haematology
, 202
(3)
pp. 498-503.
10.1111/bjh.18894.
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Abstract
Limited data exist on COVID-19 vaccination efficacy in patients with acute myeloid leukemia and myelodysplasia with excess blasts (AML/MDS-EB2). We report results from a prospective study, PACE (Patients with AML and COVID-19 Epidemiology). 93 patients provided samples post-vaccine 2 or 3 (PV2, PV3). Antibodies against SARS-COV-2 spike antigen were detectable in all samples. Neutralization of the omicron variant was poorer than ancestral variants but improved PV3. In contrast, adequate T-cell reactivity to SARS-COV-2 spike protein was seen in only 16/47 (34%) patients PV2 and 23/52 (44%) PV3. Using regression models, disease response (not in CR/Cri), and increasing age predicted poor T cell response.
| Type: | Article |
|---|---|
| Title: | Defective T-cell response to COVID-19 vaccination in acute myeloid leukaemia and myelodysplastic syndromes |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bjh.18894 |
| Publisher version: | https://doi.org/10.1111/bjh.18894 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | AML, COVID, Hematology, Life Sciences & Biomedicine, MDS, Science & Technology, vaccination |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10207665 |
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