Lankina, Anastasia;
Raposo, Marta;
Hargreaves, Alexander;
Atknson, Claire;
Griffiths, Paul;
Reeves, Matthew;
(2025)
Developing a Vaccine Against Human Cytomegalovirus: Identifying and Targeting HCMV’s Immunological Achilles’ Heel.
Vaccines
, 13
(5)
, Article 435. 10.3390/vaccines13050435.
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Abstract
Human cytomegalovirus (HCMV) is a critical pathogen in immunocompromised populations, such as organ transplant recipients as well as congenitally infected neonates with immature immune systems. Despite decades of research and the growing financial burden associated with the management of HCMV, there is no licensed vaccine to date. In this review, we aim to outline the complexity of HCMV and the antigens it presents and the journey and challenges of developing an effective HCMV vaccine, as well as further highlight the recent analyses of the most successful vaccine candidate so far—gB/MF59.
| Type: | Article |
|---|---|
| Title: | Developing a Vaccine Against Human Cytomegalovirus: Identifying and Targeting HCMV’s Immunological Achilles’ Heel |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/vaccines13050435 |
| Publisher version: | https://doi.org/10.3390/vaccines13050435 |
| Language: | English |
| Additional information: | © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | HCMV; virus; glycoprotein; mRNA; transplant |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10207610 |
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