López-Otín, Carlos;
Blasco, Maria A;
Partridge, Linda;
Serrano, Manuel;
Kroemer, Guido;
(2023)
Hallmarks of aging: An expanding universe.
Cell
, 186
(2)
pp. 243-278.
10.1016/j.cell.2022.11.001.
Preview |
Text (Article)
Partridge_HoA-FinalREV_cwGK copy 2.pdf Download (1MB) | Preview |
Preview |
Text (Figures)
Partridge_HoA FINAL Figs RevRev.pdf Download (3MB) | Preview |
Abstract
Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them. We propose the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected among each other, as well as to the recently proposed hallmarks of health, which include organizational features of spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress.
| Type: | Article |
|---|---|
| Title: | Hallmarks of aging: An expanding universe |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cell.2022.11.001 |
| Publisher version: | https://doi.org/10.1016/j.cell.2022.11.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10207541 |
Archive Staff Only
 |
View Item |
