Lee, Chang Woo;
Jia, Wei;
Norman, Roanna;
Dando, Alex;
Swain, Susan;
Hilder, Francesca;
Flubacher, Maxine;
... King, Emma V; + view all
(2025)
Oncological and functional outcomes for transoral robotic surgery versus radiotherapy in T1-2 N0-1 p16+ oropharyngeal carcinoma.
The Journal of Laryngology & Otology
, 139
(8)
pp. 730-737.
10.1017/S0022215125000350.
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Abstract
Objectives: Oncological and functional outcomes for T1-2 N0-1 (TNMv8) p16-positive oropharyngeal squamous cell carcinoma patients were analysed according to treatment: either transoral robotic surgery (TORS) (Surgery group – TORS and neck dissection ± adjuvant radiotherapy/chemoradiotherapy) or primary radiotherapy/chemoradiotherapy (Oncology group). / Methods: Single-centre retrospective observational study. / Results: The two-year disease-free survival rate was 88 per cent for the Oncology group (n = 42) and 95 per cent for the Surgery group (n = 44). The two-year overall survival rate was 98 per cent for the Oncology group and 100 per cent for the Surgery group. The functional swallowing outcome at two years post-treatment was similar in both groups. Subgroup analysis showed patients treated with surgery-only with no adjuvant treatment had the best functional outcome whilst patients treated with surgery and post-operative chemoradiotherapy had the worst functional outcome. / Conclusion: The overall oncological and functional outcomes at two years were similar in both groups. Patients treated with surgery-only had the best functional outcome without compromised oncological outcome.
| Type: | Article |
|---|---|
| Title: | Oncological and functional outcomes for transoral robotic surgery versus radiotherapy in T1-2 N0-1 p16+ oropharyngeal carcinoma |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1017/S0022215125000350 |
| Publisher version: | https://doi.org/10.1017/S0022215125000350 |
| Language: | English |
| Additional information: | This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Oncology, Oropharynx, Swallowing, Head and Neck Cancer, Head and Neck Surgery |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10207375 |
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