Maitusong, Buamina;
Laguzzi, Federica J;
Strawbridge, Rona;
Baldassarre, Damiano;
Veglia, Fabrizio E;
Humphries, Steve;
Savonen, Kai;
... Leander, Karin; + view all
(2023)
Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study.
Circulation: Genomic and Precision Medicine
, 16
(3)
pp. 236-247.
10.1161/CIRCGEN.122.003710.
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Abstract
Background: Smoking is associated with carotid intima-media thickness (C-IMT). However, knowledge about how genetics may influence this association is limited. We aimed to perform nonhypothesis driven gene-smoking interaction analyses to identify potential genetic variants, among those included in immune and metabolic platforms, that may modify the effect of smoking on carotid intima-media thickness. Methods: We used baseline data from 1551 men and 1700 women, aged 55 to 79, included in a European multi-center study. Carotid intima-media thickness maximum, the maximum of values measured at different locations of the carotid tree, was dichotomized with cut point values ≥75, respectively. Genetic data were retrieved through use of the Illumina Cardio-Metabo- and Immuno- Chips. Gene-smoking interactions were evaluated through calculations of Synergy index (S). After adjustments for multiple testing, P values of <2.4×10-7for S were considered significant. The models were adjusted for age, sex, education, physical activity, type of diet, and population stratification. Results: Our screening of 207 586 SNPs available for analysis, resulted in the identification of 47 significant gene-smoking synergistic interactions in relation to carotid intima-media thickness maximum. Among the significant SNPs, 28 were in protein coding genes, 2 in noncoding RNA and the remaining 17 in intergenic regions. Conclusions: Through nonhypothesis-driven analyses of gene-smoking interactions, several significant results were observed. These may stimulate further research on the role of specific genes in the process that determines the effect of smoking habits on the development of carotid atherosclerosis.
| Type: | Article |
|---|---|
| Title: | Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1161/CIRCGEN.122.003710 |
| Publisher version: | https://doi.org/10.1161/circgen.122.003710 |
| Language: | English |
| Additional information: | © 2023 The Authors. Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Genetics & Heredity, Cardiovascular System & Cardiology, carotid intima-media thickness, epidemiologic studies, gene-environment interaction, polymorphism, single nucleotide, smoking, INTIMA-MEDIA THICKNESS, GENOME-WIDE ASSOCIATION, CARDIOVASCULAR-DISEASE RISK, CORONARY-ARTERY-DISEASE, CAROTID ATHEROSCLEROSIS, CIGARETTE-SMOKING, APOLIPOPROTEIN-E, HEART-DISEASE, MYOCARDIAL-INFARCTION, VASCULAR EVENTS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10207123 |
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