Fedeli, Valeria;
Wang, Jingyi;
Cantagrel, Vincent;
Saiardi, Adolfo;
(2024)
Human plasma inositol hexakisphosphate (InsP 6 ) phosphatase identified as the Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1).
microPublication Biology
pp. 1-7.
10.17912/micropub.biology.001390.
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Human plasma inositol hexakisphosphate (InsP sub6sub ) phosphatase identified as the Multiple Inositol Polyphosphate Phospha.pdf - Published Version Download (586kB) | Preview |
Abstract
Inositol hexakisphosphate (InsP 6 ), also known as phytic acid, is a potent chelator of bivalent cations. Intracellular InsP 6 molecules are associated with magnesium. Calcium is the prevalent bivalent cation outside the cell and its association with InsP 6 could lead to the formation of insoluble complexes. To avoid the formation of dangerous InsP 6 /Calcium precipitates in the bloodstream, mammals must possess a robust InsP 6 phosphatase in their plasma. Here we identify the Multiple Inositol Polyphosphate Phosphatase 1 ( MINPP1 ) as the InsP 6 phosphatase present in human plasma.
| Type: | Article |
|---|---|
| Title: | Human plasma inositol hexakisphosphate (InsP 6 ) phosphatase identified as the Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.17912/micropub.biology.001390 |
| Publisher version: | https://doi.org/10.17912/micropub.biology.001390 |
| Language: | English |
| Additional information: | © 2024 by the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/deed.en). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10207082 |
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