Mattana, Ariane Marie;
(2025)
Development of biocatalytic methods for the synthesis of chiral sulfur compounds bearing a C(sp3)-S stereocentre.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
Chiral sulfur compounds are essential motifs in organic and medicinal chemistry. Current traditional methods for their synthesis are not only challenging but they also pose a risk to the environment and human health. Biocatalysis has become an increasingly appealing strategy to replace synthetic methods for the formation of carbon stereocentres. However, the use of enzymes for the synthesis of carbon-sulfur stereocentres remains very limited and is often restricted to enzymatic kinetic resolutions. This thesis reports on the development of several biocatalytic pathways to access carbon-sulfur stereocentres from a variety of substrates. Firstly, ENE-reductase is used for the formation of chiral
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Development of biocatalytic methods for the synthesis of chiral sulfur compounds bearing a C(sp3)-S stereocentre |
| Language: | English |
| Additional information: | Copyright © The Author 2025. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10206735 |
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