Altaher, Jenan;
(2025)
Exploring the Impact of Amelogenesis Imperfecta on Oral Health
Related Quality of Life in Children and Young Persons.
Doctoral thesis (D.Dent), UCL (University College London).
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Abstract
INTRODUCTION: Amelogenesis Imperfecta (AI) can significantly impact the oral health-related quality of life (OHRQoL) of affected children and young persons (CYP). This thesis explores the multifaceted challenges associated with AI and evaluates the efficacy of patient- reported outcome measures (PROMs) and clinician feedback to inform patient-centred care. AIMS AND OBJECTIVES: To investigate the impact of AI on OHRQoL from both patient and clinician perspectives. This study includes a scoping review to explore existing research on the relationship between developmental enamel defects (DED) and OHRQoL in children and young persons (CYP). Other key objectives of this project included evaluating the utility and limitations of the AI PROM in clinical practice, identifying age- and treatment- specific trends in patient-reported outcomes, and gathering clinician recommendations for improving the tool. METHODOLOGY: This mixed-methods research involved a scoping review and a retrospective service evaluation of AI PROM responses from CYP at pre- and mid-treatment stages, as well as a survey capturing paediatric dentists’ feedback on the tool. The scoping review followed the Joanna Briggs Institute (JBI) methodology for scoping reviews and aimed to map the breadth of literature on the relationship between DED and OHRQoL in CYP. The retrospective service evaluation analysed AI PROM data collected at EDH, identifying trends and patterns quantitatively, while thematic analysis provided qualitative insights. The clinician survey, detailed in Appendix 2, was analysed to capture feedback on the AI PROM's implementation and effectiveness in clinical practice. RESULTS: The scoping review identified 25 studies, predominantly focusing on MIH and psychological impacts, while highlighting gaps in research on AI and its impacts on OHRQoL. Analysis of 68 AI PROM responses, collected at EDH, revealed age-specific patterns, with younger children facing functional challenges and adolescents experiencing psychosocial distress. Subgroup analysis highlighted greater challenges for Hypoplastic AI cases. The clinician survey (30.8% response rate) confirmed the AI PROM’s utility in improving communication and planning but noted challenges like workflow integration and capturing specific patient concerns. This research underscores the need for a refined AI PROM and multidisciplinary, patient-centred approaches to enhance outcomes and quality of life for CYP with AI.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | D.Dent |
| Title: | Exploring the Impact of Amelogenesis Imperfecta on Oral Health Related Quality of Life in Children and Young Persons |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2025. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10206702 |
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