Yuan, Yu;
Jaslan, Dawid;
Rahman, Taufiq;
Bracher, Franz;
Grimm, Christian;
Patel, Sandip;
(2024)
Coordinating activation of endo-lysosomal two-pore channels and TRP mucolipins.
The Journal of Physiology
, 602
(8)
pp. 1623-1636.
10.1113/JP283829.
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Abstract
Two-pore channels and TRP mucolipins are ubiquitous endo-lysosomal cation channels of pathophysiological relevance. Both are Ca2+-permeable and regulated by phosphoinositides, principally PI(3,5)P2. Accumulating evidence has uncovered synergistic channel activation by PI(3,5)P2 and endogenous metabolites such as the Ca2+ mobilizing messenger NAADP, synthetic agonists including approved drugs and physical cues such as voltage and osmotic pressure. Here, we provide an overview of this coordination. (Figure presented.).
| Type: | Article |
|---|---|
| Title: | Coordinating activation of endo-lysosomal two-pore channels and TRP mucolipins |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1113/JP283829 |
| Publisher version: | https://doi.org/10.1113/jp283829 |
| Language: | English |
| Additional information: | © 2024 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | calcium channel, lysosomes, NAADP, PI(3,5)P2, TPC1, TPC2, TRPML1, TRPML2 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10206390 |
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