Alhassan, Alaa Sultan;
(2025)
The Impact of Dentinogenesis Imperfecta on Children’s Oral Health-Related Quality of Life.
Doctoral thesis (D.Dent), UCL (University College London).
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Abstract
Background: Children with Dentinogenesis Imperfecta (DI) usually require lifelong specialist dental care. The impact of DI on the oral health-related quality of life (OHRQoL) in children is unknown. Aims and objectives: The project aimed to provide a better understanding of how DI can impact on the OHRQoL. The objectives were as follow: • To explore the current DI management and the success or failure of different treatment modalities. • To assess the dental care burden for children and young people with isolated DI. • To provide an insight into how children with DI feel about their teeth and smile by investigating the symptoms they have and whether they’re satisfied about their dental appearance/ function. Methods: Part one: scoping review on the dental management of children with DI – all available peer-reviewed articles (literature, scoping, and systematic reviews) were reviewed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA -ScR). Part two: service evaluation of the burden of dental care – retrospective analysis of children with isolated DI records was conducted. Part Three: Development of a PROM questionnaire specific to DI – this was created based on clinicians’ inputs and patient’s concerns and was piloted and changes made. Following local approvals, the DI PROM was used on 13 children with DI. Results: Seven articles were reviewed on DI management in children. This provided an insight into the association of DI with other dental anomalies and malocclusion, treatment challenges, and its psychological impact. The service evaluation included 36 patients with isolated DI; 28% had travelled 30-60 miles and 25% had travelled over 120 miles to attend appointments. Inhalation and general anaesthesia were commonly used to provide treatment. Many failed restorations were noted, and some children had additional dental anomalies which required a multidisciplinary input. The PROMs pilot involved 13 patients and showed issues such as pain, eating difficulties, and concerns about dental appearance. Bullying was also a concern. Conclusion: Managing DI effectively requires a multidisciplinary approach, and children can present with a range of treatment challenges. DI has a high burden of dental care and can also be associated with other dental anomalies and related malocclusion. The PROM questionnaire highlighted a range of concerns and complications demonstrating the likely impact of DI on the oral health-related quality of life in paediatric patients and overall well-being.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | D.Dent |
| Title: | The Impact of Dentinogenesis Imperfecta on Children’s Oral Health-Related Quality of Life |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2025. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10206023 |
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