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Developing an adaptive platform trial for evaluation of medical treatments for Crohn's disease

Noor, Nurulamin M; Radford, Shellie J; Choodari-Oskooei, Babak; Gordon, Morris; Hart, Ailsa L; Hepburn, Trish; Juszczak, Ed; ... Moran, Gordon W; + view all (2025) Developing an adaptive platform trial for evaluation of medical treatments for Crohn's disease. Nature Reviews Gastroenterology & Hepatology , 22 pp. 364-366. 10.1038/s41575-025-01052-0. Green open access

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Abstract

There is emerging interest in adaptive platform trials for inflammatory bowel disease. In this Comment, we present the results of a workshop that was convened to consider the opportunities and challenges of developing a platform trial in Crohn’s disease.

Type: Article
Title: Developing an adaptive platform trial for evaluation of medical treatments for Crohn's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41575-025-01052-0
Publisher version: https://doi.org/10.1038/s41575-025-01052-0
Language: English
Additional information: This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Clinical trials, Crohn's disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10205802
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