Zhang, C;
Xu, X;
Li, B;
Li, H;
Tan, X;
Justin Jesuraj, P;
Xie, W;
(2025)
Ultra sensitive and low detection limitation non-enzymatic glucose biosensor based on heterojunction NiO@In2O3 hollow nanofibers.
Microchemical Journal
, 208
, Article 112401. 10.1016/j.microc.2024.112401.
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MICROC-D-24-06925_R1-21-42.pdf - Accepted Version Access restricted to UCL open access staff until 14 December 2025. Download (1MB) |
Abstract
In recent years, metal oxides and their composites have been rapidly developed for non-enzymatic glucose sensors. Nevertheless, metal oxides exhibit relatively high electrical resistance, and their selectivity and signal-to-noise ratio for low-concentration glucose detection still require improvement. We here developed a NiO@In2O3 hollow nanofibers-based glucose biosensor with excellent performance. The heterojunction of NiO@In2O3 hollow nanofibers is obtained via a two-step process involving electrospinning and hydrothermal methods, respectively. The resulting sensor exhibits good activity as an electrocatalyst for the oxidation of glucose, with an ultralow limit of detection (LOD) of 2 nM and a good sensitivity of 1147 µA mM−1 cm−2, in line with excellent long-term stability, reproducibility, and good selectivity. These high-performance sensor are validated by monitoring glucose levels in human saliva. It demonstrates that heterojunction of NiO@In2O3 hollow nanofibers can be used as effective electrochemical sensing materials in practical biological applications.
| Type: | Article |
|---|---|
| Title: | Ultra sensitive and low detection limitation non-enzymatic glucose biosensor based on heterojunction NiO@In2O3 hollow nanofibers |
| DOI: | 10.1016/j.microc.2024.112401 |
| Publisher version: | https://doi.org/10.1016/j.microc.2024.112401 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Glucose biosensor, Electrochemical detection, Saliva, Hollow nanofibers, Ultra-low detection limit |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office > Institute for Materials Discovery |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10205725 |
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