Hubacek, Jaroslav A;
Capkova, Nadezda;
Bobak, Martin;
Pikhart, Hynek;
(2024)
Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study.
International Journal of Infectious Diseases
, 148
, Article 107232. 10.1016/j.ijid.2024.107232.
(In press).
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Abstract
Objectives: COVID-19 caused a global pandemic with millions of deaths. Fat mass and obesity-associated gene (FTO) (alias m6A RNA demethylase) and its functional rs17817449 polymorphism are candidates to influence COVID-19-associated mortality since methylation status of viral nucleic acids is an important factor influencing viral viability. Methods: We tested a population-based cohort of 5233 subjects (aged 63-87 years in 2020) where 70 persons died from COVID-19 and 394 from other causes during the pandemic period. Results: The frequency of GG homozygotes was higher among those who died from COVID-19 (34%) than among survivors (19%) or deaths from other causes (20%), P <0.005. After multiple adjustments, GG homozygotes had a higher risk of death from COVID-19 with odds ratio = 2.01 (95% confidence interval; 1.19-3.41, P <0.01) compared with carriers of at least one T allele. The FTO polymorphism was not associated with mortality from other causes. Conclusions: Our results suggest that FTO variability is a significant predictor of COVID-19-associated mortality in Caucasians.
| Type: | Article |
|---|---|
| Title: | Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study |
| Location: | Canada |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijid.2024.107232 |
| Publisher version: | https://doi.org/10.1016/j.ijid.2024.107232 |
| Language: | English |
| Additional information: | © 2024 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, COVID-19, SARS-CoV-2, FTO, Mortality, Polymorphism, FTO GENE, OBESITY, VARIANT, SUSCEPTIBILITY, CHILDHOOD, DISEASE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10205317 |
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