Vélez-Fort, Mateo;
Cossell, Lee;
Porta, Laura;
Clopath, Claudia;
Margrie, Troy W;
(2025)
Motor and vestibular signals in the visual cortex permit the separation of self versus externally generated visual motion.
Cell
10.1016/j.cell.2025.01.032.
(In press).
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Abstract
Knowing whether we are moving or something in the world is moving around us is possibly the most critical sensory discrimination we need to perform. How the brain and, in particular, the visual system solves this motion-source separation problem is not known. Here, we find that motor, vestibular, and visual motion signals are used by the mouse primary visual cortex (VISp) to differentially represent the same visual flow information according to whether the head is stationary or experiencing passive versus active translation. During locomotion, we find that running suppresses running-congruent translation input and that translation signals dominate VISp activity when running and translation speed become incongruent. This cross-modal interaction between the motor and vestibular systems was found throughout the cortex, indicating that running and translation signals provide a brain-wide egocentric reference frame for computing the internally generated and actual speed of self when moving through and sensing the external world.
| Type: | Article |
|---|---|
| Title: | Motor and vestibular signals in the visual cortex permit the separation of self versus externally generated visual motion |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cell.2025.01.032 |
| Publisher version: | https://doi.org/10.1016/j.cell.2025.01.032 |
| Language: | English |
| Additional information: | © The Author(s), 2025. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | motor, vestibular, locomotion, visual flow, translation, primary visual cortex, mouse, in vivo, running, rate-based modeling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10205185 |
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