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Preconception indicators and associations with health outcomes reported in UK routine primary care data: a systematic review

Schoenaker, Danielle; Lovegrove, Elizabeth M; Cassinelli, Emma H; Hall, Jennifer; Mcgranahan, Majel; Mcgowan, Laura; Carr, Helen; ... Godfrey, Keith M; + view all (2025) Preconception indicators and associations with health outcomes reported in UK routine primary care data: a systematic review. British Journal of General Practice (BJGP) , 75 (751) e129-e136. 10.3399/BJGP.2024.0082. Green open access

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Abstract

Background Routine primary care data may be a valuable resource for preconception health research and to inform the provision of preconception care. Aim To review how primary care data could provide information on the prevalence of preconception indicators and examine associations with maternal and offspring health outcomes. Design and setting Systematic review of observational studies using UK routine primary care data. Method Literature searches were conducted in March 2023 using five databases to identify observational studies that used national primary care data from individuals aged 15–49 years. Preconception indicators were defined as medical, behavioural, and social factors that may impact future pregnancies; health outcomes included those that may occur during and after pregnancy. Results From 5259 screened records, 42 articles were included. The prevalence of 37 preconception indicator measures was described for female patients, ranging from 0.01% for sickle cell disease to >20% for each of advanced maternal age, previous caesarean section (among those with a recorded pregnancy), overweight, obesity, smoking, depression, and anxiety (irrespective of pregnancy). Few studies reported indicators for male patients (n = 3) or associations with outcomes (n = 5). Most studies had a low risk of bias, but missing data may limit generalisability of the findings. Conclusion The findings demonstrated that routinely collected UK primary care data could be used to identify patients’ preconception care needs. Linking primary care data with health outcomes collected in other datasets is underutilised, but could help to quantify how optimising preconception health and care could reduce adverse outcomes for mothers and children.

Type: Article
Title: Preconception indicators and associations with health outcomes reported in UK routine primary care data: a systematic review
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.3399/BJGP.2024.0082
Publisher version: https://doi.org/10.3399/bjgp.2024.0082
Language: English
Additional information: This article is Open Access: CC BY 4.0 licence (http://creativecommons.org/ licences/by/4.0/).
Keywords: Science & Technology, Life Sciences & Biomedicine, Primary Health Care, Medicine, General & Internal, General & Internal Medicine, general practice, preconception care, pregnancy, pregnancy outcomes, pre- pregnancy care, primary care, EMERGENCY CONTRACEPTION, ORAL-CONTRACEPTIVES, WOMEN, POPULATION, PREGNANCY, RISK, PREVALENCE, PROVISION, PATTERNS, ENGLAND
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health
URI: https://discovery.ucl.ac.uk/id/eprint/10204805
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