Zhuo, Zhizheng;
Zhang, Ningnannan;
Ao, Feng;
Hua, Tiantian;
Duan, Yunyun;
Xu, Xiaolu;
Weng, Jinyuan;
... Liu, Yaou; + view all
(2024)
Spatial structural abnormality maps associated with cognitive and physical performance in relapsing-remitting multiple sclerosis.
European Radiology
10.1007/s00330-024-11157-w.
(In press).
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Barkhof_Zhou - Spatial structural abnormality maps associated with cognitive and physical performance in relapsing-remitting multiple sclerosis - Eur_Radiol_.pdf Access restricted to UCL open access staff until 30 October 2025. Download (290kB) |
Abstract
Objectives: We aimed to characterize the brain abnormalities that are associated with the cognitive and physical performance of patients with relapsing-remitting multiple sclerosis (RRMS) using a deep learning algorithm. // Materials and methods: Three-dimensional (3D) nnU-Net was employed to calculate a novel spatial abnormality map by T1-weighted images and 281 RRMS patients (Dataset-1, male/female = 101/180, median age [range] = 35.0 [17.0, 65.0] years) were categorized into subtypes. Comparison of clinical and MRI features between RRMS subtypes was conducted by Kruskal–Wallis test. Kaplan–Meier analysis was conducted to investigate disability progression in RRMS subtypes. Additional validation using two other RRMS datasets (Dataset-2, n = 33 and Dataset-3, n = 56) was conducted. // Results: Five RRMS subtypes were identified: (1) a Frontal-I subtype showing preserved cognitive performance and mild physical disability, and low risk of disability worsening; (2) a Frontal-II subtype showing low cognitive scores and severe physical disability with significant brain volume loss, and a high propensity for disability worsening; (3) a temporal-cerebellar subtype demonstrating lowest cognitive scores and severest physical disability among all subtypes but remaining relatively stable during follow-up; (4) an occipital subtype demonstrating similar clinical and imaging characteristics as the Frontal-II subtype, except a large number of relapses at baseline and preserved cognitive performance; and (5) a subcortical subtype showing preserved cognitive performance and low physical disability but a similar prognosis as the occipital and Frontal-II subtypes. Additional validation confirmed the above findings. // Conclusion: Spatial abnormality maps can explain heterogeneity in cognitive and physical performance in RRMS and may contribute to stratified management.
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