Anderson, David G;
Ferreira-Correia, Aline;
Rodrigues, Filipe B;
Byrne, Lauren M;
Wild, Edward J;
Krause, Amanda;
(2024)
Comparative analysis of neurofilament light chain in Huntington's disease like 2 and Huntington's disease.
Journal of Huntington's Disease
10.1177/18796397241300141.
(In press).
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Abstract
Huntington's disease-like 2 (HDL2) closely resembles Huntington's disease (HD) in clinical and pathological features. Neurofilament light chain (NfL) is an important biomarker in HD research and holds potential in HDL2. To evaluate NfL's utility in HDL2, a comparative analysis among HDL2 (n = 12), HD (n = 9), and unaffected controls (n = 9) was conducted. Employing a cross-sectional design, NfL levels were assessed in blood plasma. Concentrations were notably elevated in both HD and HDL2 groups compared to controls. HD patients displayed higher NfL levels than HDL2, possibly reflecting disease duration differences. NfL effectively distinguished HDL2 from controls, highlighting its promise as a possible biomarker in HDL2 research.
| Type: | Article |
|---|---|
| Title: | Comparative analysis of neurofilament light chain in Huntington's disease like 2 and Huntington's disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/18796397241300141 |
| Publisher version: | https://doi.org/10.1177/18796397241300141 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Huntington's disease; Huntington's disease like 2; HDL2; neurofilament light chain; biomarkers; Huntington's disease phenocopies; South Africa |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10204757 |
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