Crane, James D; Joy, George; Knott, Kristopher D; Augusto, João B; Lau, Clement; Bhuva, Anish N; Seraphim, Andreas; ... Manisty, Charlotte; + view all Crane, James D; Joy, George; Knott, Kristopher D; Augusto, João B; Lau, Clement; Bhuva, Anish N; Seraphim, Andreas; Evain, Timothée; Brown, Louise AE; Chowdhary, Amrit; Kotecha, Tushar; Fontana, Marianna; Plein, Sven; Ramar, Sasindran; Rubino, Francesco; Kellman, Peter; Xue, Hui; Pierce, Iain; Davies, Rhodri H; Moon, James C; Cruickshank, J Kennedy; McGowan, Barbara M; Manisty, Charlotte; - view fewer (2024) The Impact of Bariatric Surgery on Coronary Microvascular Function Assessed Using Automated Quantitative Perfusion CMR. JACC Cardiovasc Imaging , 17 (11) pp. 1305-1316. 10.1016/j.jcmg.2024.05.022.

Text Joy-JIMG111323-1595-TR1[304895].pdf - Accepted Version Access restricted to UCL open access staff until 5 November 2025. Download (491kB)

Abstract

BACKGROUND: Coronary microvascular function is impaired in patients with obesity, contributing to myocardial dysfunction and heart failure. Bariatric surgery decreases cardiovascular mortality and heart failure, but the mechanisms are unclear. OBJECTIVES: The authors studied the impact of bariatric surgery on coronary microvascular function in patients with obesity and its relationship with metabolic syndrome. METHODS: Fully automated quantitative perfusion cardiac magnetic resonance and metabolic markers were performed before and 6 months after bariatric surgery. RESULTS: Compared with age- and sex-matched healthy volunteers, 38 patients living with obesity had lower stress myocardial blood flow (MBF) (P = 0.001) and lower myocardial perfusion reserve (P < 0.001). A total of 27 participants underwent paired follow-up 6 months post-surgery. Metabolic abnormalities reduced significantly at follow-up including mean body mass index by 11 ± 3 kg/m2 (P < 0.001), glycated hemoglobin by 9 mmol/mol (Q1-Q3: 4-19 mmol/mol; P < 0.001), fasting insulin by 142 ± 131 pmol/L (P < 0.001), and hepatic fat fraction by 5.6% (2.6%-15.0%; P < 0.001). Stress MBF increased by 0.28 mL/g/min (-0.02 to 0.75 mL/g/min; P = 0.003) and myocardial perfusion reserve by 0.13 (-0.25 to 1.1; P = 0.036). The increase in stress MBF was lower in those with preoperative type 2 diabetes mellitus (0.1 mL/g/min [-0.09 to 0.46 mL/g/min] vs 0.75 mL/g/min [0.31-1.25 mL/g/min]; P = 0.002). Improvement in stress MBF was associated with reduction in fasting insulin (beta = -0.45 [95% CI: -0.05 to 0.90]; P = 0.03). CONCLUSIONS: Coronary microvascular function is impaired in patients with obesity, but can be improved significantly with bariatric surgery. Improvements in microvascular function are associated with improvements in insulin resistance but are attenuated in those with preoperative type 2 diabetes mellitus.

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