Watt, Fraser Traquair;
(2025)
Freehand Optical Ultrasound Probes for Real-Time Multimodal Imaging.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
Optical ultrasound (OpUS) imaging is an ultrasound modality that utilises light to generate and detect ultrasound, without the need for conventional electronic ultrasound transducers. Recently, a novel form of freehand OpUS probe has been demonstrated to be capable of performing real-time, video-rate ultrasound imaging using an array of fibre optic sources and a single detector. These probes can be constructed entirely from glass optical fibres and plastic components. It has been proposed that these probes would be inherently compatible with a range of other imaging and treatment modalities, particularly those that use intense electromagnetic fields such as computed tomography (CT) and magnetic resonance imaging (MRI). However, to date, this capacity for multimodal imaging has not been demonstrated. Here, the development of the next generation of freehand OpUS probes is presented, with the goal of demonstrating improved OpUS imaging performance, and to investigate the proposed multimodal imaging capabilities. A novel freehand OpUS probe is presented that utilises an array of eccentric optical waveguides to shape the generated ultrasound fields for improved ultrasound penetration depths. Video-rate imaging speeds of up to 24 Hz were achieved through the implementation of GPU-enabled ultrasound beamformers, and an accompanying mobile OpUS acquisition platform was developed to enable the first demonstration of freehand OpUS imaging in a clinical environment as well as on human volunteers. This system was then used to perform the first concurrent OpUS-CT and OpUS-MRI imaging experiments. Finally, an endoluminal-scale freehand OpUS probe was developed with a design that employed a significantly increased channel count, optical hologram-based light shaping and newly-developed fabrication techniques to bring the image quality of OpUS probes closer to clinical relevance. The work in this thesis represents several significant steps towards the clinical translation of the freehand OpUS paradigm, and the multimodal imaging demonstration is a significant milestone for the OpUS paradigm as a whole.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Freehand Optical Ultrasound Probes for Real-Time Multimodal Imaging |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2025. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10204371 |
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