Garg, Saweta;
Singla, Pankaj;
Kaur, Sarbjeet;
Canfarotta, Francesco;
Velliou, Eirini;
Dawson, James A;
Kapur, Nikil;
... Peeters, Marloes; + view all
(2025)
Future Perspectives on the Automation and Biocompatibility of Molecularly Imprinted Polymers for Healthcare Applications.
Macromolecules
10.1021/acs.macromol.4c01621.
(In press).
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Abstract
Molecular recognition is of crucial importance in several healthcare applications, such as sensing, drug delivery, and therapeutics. Molecularly imprinted polymers (MIPs) present an interesting alternative to biological receptors (e.g., antibodies, enzymes) for this purpose since synthetic receptors overcome the limited robustness, flexibility, high-cost, and potential for inhibition that comes with natural recognition elements. However, off the shelf MIP products remain limited, which is likely due to the lack of a scalable production approach that can manufacture these materials in high yields and narrow and defined size distributions to have full control over their properties. In this Perspective, we will confer how breakthroughs in the automation of MIP design, manufacturing, and evaluation of performance will accelerate the (commercial) implementation of MIPs in healthcare technology. In addition, we will discuss how prediction of the in vivo behavior of MIPs with animal-free technologies (e.g., 3D tissue models) will be critical to assess their clinical potential.
| Type: | Article |
|---|---|
| Title: | Future Perspectives on the Automation and Biocompatibility of Molecularly Imprinted Polymers for Healthcare Applications |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.macromol.4c01621 |
| Publisher version: | https://doi.org/10.1021/acs.macromol.4c01621 |
| Language: | English |
| Additional information: | Copyright © 2025 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Immunology, Materials, Monomers, Peptides And Proteins, Polymers |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10204297 |
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