Wang, Xiaomeng;
Leng, Shuang;
Adamson, Philip D;
Greer, Charlotte E;
Huang, Weimin;
Lee, Hwee Kuan;
Loong, Yan Ting;
... Baskaran, Lohendran; + view all
(2025)
Characterizing Cardiac Adipose Tissue in Post-AMI Patients via CT Imaging: A Comparative Cross-sectional Study.
European Heart Journal: Cardiovascular Imaging
, Article jeaf019. 10.1093/ehjci/jeaf019.
(In press).
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Abstract
Aims: To identify differences in CT-derived perivascular (PVAT) and epicardial adipose tissue (EAT) characteristics that may indicate inflammatory status differences between post-treatment acute myocardial infarction (AMI) and stable coronary artery disease (CAD) patients. // Methods and Results: A cohort of 205 post-AMI patients (age 59.8±9.2, 92.2% male) was propensity-matched with 205 stable CAD patients (age 60.5±10.0, 90.2% male). Coronary CT angiography and non-contrast CT scans were performed to assess PVAT mean attenuation across major coronary segments and EAT mean attenuation and volumes, respectively. For post-AMI patients, CT scans were conducted 28.6 ± 13.8 days after the AMI incidence. Post-AMI patients showed higher non-culprit PVAT and EAT mean attenuation than stable CAD patients (8.01HU, 95% CI 5.90 to 10.11 HU, p<0.001, 2.48 HU, 95% CI 0.83 to 4.13 HU, p=0.003, respectively). The EAT volume percentage at higher attenuation levels was higher in post-AMI patients compared to stable CAD (33.93cm3, 95% CI 16.86 to 51.00 cm3, p<0.001), with the difference maximized at the -70 HU threshold (4.75%, 95% CI 3.64% to 5.87%, p<0.001). PVAT mean attenuation positively correlated with EAT mean attenuations and the percentage of EAT volume >-70 HU (p<0.001 for both). // Conclusions: Post-AMI patients showed higher PVAT and EAT attenuation than stable CAD patients, potentially indicating AMI-associated inflammatory cardiac adipose tissue changes. -70 HU can act as a potential cut-off for inflamed EAT. These findings highlight the potential of using CT-derived adipose tissue characteristics to assess inflammation and guide post-AMI management strategies.
| Type: | Article |
|---|---|
| Title: | Characterizing Cardiac Adipose Tissue in Post-AMI Patients via CT Imaging: A Comparative Cross-sectional Study |
| Location: | England |
| DOI: | 10.1093/ehjci/jeaf019 |
| Publisher version: | https://doi.org/10.1093/ehjci/jeaf019 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Acute myocardial infarction, computed tomography, perivascular adipose tissue, epicardial adipose tissue |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10204230 |
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