Habibollahi, Maryam;
Jiang, Dai;
Lancashire, Henry Thomas;
Demosthenous, Andreas;
(2025)
An Active Microchannel Neural Interface for Implantable Electrical Stimulation and Recording.
IEEE Transactions on Biomedical Circuits and Systems
pp. 1-13.
10.1109/tbcas.2025.3533612.
(In press).
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Abstract
A mm-sized, implantable neural interface for bidirectional control of the peripheral nerves with microchannel electrodes is presented in this paper. The application-specific integrated circuit (ASIC) developed in a 0.18 μm CMOS technology is designed to achieve highly selective, concurrent control of 300-μm-wide groups of small nerve sections. It has in-situ, high-voltage-compliant (45 V) electrical stimulation and low-voltage (1.8 V) neural recording in each channel. Biphasic stimulus current pulses up to 124 μA with a 2 μA resolution are generated between 7.4 Hz and 20 kHz frequencies to stimulate and block neural activity. Action potentials are measured across a 10 kHz bandwidth with a variable gain response that ranges up to 72 dB. The neural recording front-end implements a low-power and low-noise biopotential amplifier with an input-referred noise (IRN) of 2.74 μVrms across the full measurement bandwidth. Automatic detection and reduction of stimulus artifacts is realised using a pole-shifting mechanism with a 1-ms amplifier recovery time. Versatile control of concurrently-operating channels is achieved in a two-channel, 2.31 mm2 interface ASIC using local control that allows up to seven devices to operate in parallel. Invitro validation of the active interface shows feasibility for closed-loop peripheral nerve control, while ex-vivo analyses of concurrent stimulation and recording demonstrates the measured neural response to electrical stimuli.
| Type: | Article |
|---|---|
| Title: | An Active Microchannel Neural Interface for Implantable Electrical Stimulation and Recording |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/tbcas.2025.3533612 |
| Publisher version: | https://doi.org/10.1109/tbcas.2025.3533612 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10204210 |
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