Zhang, Shaoyan;
(2025)
Miniaturised All-optical Devices for Therapy and Ultrasound Imaging in Minimally Invasive Surgery.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
Optical ultrasound (OpUS) is an emerging imaging paradigm that exhibits high imaging resolution, immunity to electromagnetic interference, and ease of miniaturisation. The use of optical fibres permits therapeutic and imaging modalities to be integrated into devices with small lateral dimensions, which are suitable for minimally invasive surgical applications. As a widely used minimally invasive procedure, laser ablation is suitable for treating conditions such as atrial fibrillation ablation, tumour resection, and stent graft in situ fenestration. Recently, imaging modalities, including intravascular ultrasound (IVUS) and magnetic resonance imaging (MRI), have been employed to monitor ablation outcomes. However, the use of these techniques was limited; for instance, MRI was limited by machine availability, high cost and low frame rate, and IVUS was limited by low imaging resolution and accuracy. This work was to develop miniaturised all-optical devices with lateral dimensions of < 1 mm that could be used in minimally invasive procedures to perform concurrent laser ablation and OpUS imaging. The fabricated device was integrated into a catheter and successfully implemented in situ stent graft laser fenestration guided by OpUS imaging in a swine model. Additionally, the device was extended to real-time tissue ablation monitoring on ex vivo porcine tissue, and the ex vivo results demonstrated the efficacy and accuracy of OpUS for lesion tracking. This work represents significant progress in OpUS imaging by incorporating it with therapeutic modality for minimally invasive surgeries.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Miniaturised All-optical Devices for Therapy and Ultrasound Imaging in Minimally Invasive Surgery |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2025. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10203044 |
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