Ogunlade, Olumide;
Ellwood, Robert;
Zhang, Edward;
Cox, Benjamin T;
Beard, Paul;
(2024)
Three-dimensional Whole-body Small animal Photoacoustic Tomography using a Multi-view Fabry-Perot scanner.
IEEE Transactions on Medical Imaging
10.1109/tmi.2024.3522220.
(In press).
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Abstract
Photoacoustic tomography (PAT) has the potential to become a widely used imaging tool in preclinical studies of small animals. This is because it can provide non-invasive, label free images of whole-body mouse anatomy, in a manner which is challenging for more established imaging modalities. However, existing PAT scanners are limited because they either do not implement a full 3-D tomographic reconstruction using all the recorded photoacoustic (PA) data and/or do not record the available 3-D PA time-series data around the mouse with sufficiently high spatial resolution ( ~100μm ), which compromises image quality in terms of resolution, imaging depth and the introduction of artefacts. In this study, we address these limitations by demonstrating an all-optical, multi-view Fabry-Perot based scanner for whole body small animal imaging. The scanner densely samples the acoustic field with a large number of detection points ( >100,000 ), evenly distributed around the mouse. The locations of the detection points were registered onto a common coordinate system, before a tomographic reconstruction using all the recorded PA time series was implemented. This enabled the acquisition of high resolution, whole-body PAT images of ex-vivo mice, with anatomical features visible across the entire cross section.
| Type: | Article |
|---|---|
| Title: | Three-dimensional Whole-body Small animal Photoacoustic Tomography using a Multi-view Fabry-Perot scanner |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/tmi.2024.3522220 |
| Publisher version: | https://doi.org/10.1109/tmi.2024.3522220 |
| Language: | English |
| Additional information: | This work was funded by the UK Engineering and Physical Sciences Research Council (EPSRC) Grant EP/T014369/1. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10202810 |
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