Dauncey, Elizabeth M;
Sheppard, Tom D;
Smith, Peter D;
Munday, Rachel H;
(2024)
Remote Alkynylation of Aliphatic Amines.
Organic Letters
, 26
(49)
pp. 10441-10446.
10.1021/acs.orglett.4c03468.
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Abstract
Advancements in transition metal catalyzed C-H activation/functionalization cascades have allowed the synthetic chemist's toolbox to be significantly expanded. Despite this, protocols for the remote alkynylation of linear aliphatic amines still remain limited. Herein, a palladium-catalyzed directing-group approach to alkynylation of aliphatic amines is disclosed. The synthetic utility was demonstrated with a gram-scale reaction and a functional group compatibility test.
| Type: | Article |
|---|---|
| Title: | Remote Alkynylation of Aliphatic Amines |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.orglett.4c03468 |
| Publisher version: | http://dx.doi.org/10.1021/acs.orglett.4c03468 |
| Language: | English |
| Additional information: | Saved FT to S: drive, checked copyright (applied 12-month embargo), improved metadata, made live (DK 11/12/2024). |
| Keywords: | Addition reactions, Additives, Amines, Chemical reactions, Reactivity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10201327 |
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