Stafford-Williams, Robert Mark;
(2024)
Interventional cardiopulmonary optical ultrasound imaging via rapid actuation.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
Minimally invasive interventional imaging is an important surgical approach that aids diagnosis and treatment in a manner that reduces recovery times and complication rates. Small, effective imaging probes are required for intralumenal interventional imaging. Optical ultrasound (OpUS) is a developing medical imaging method that uses laser light to generate ultrasound at the tip of sub-mm optical fibres photoacoustically within an optically absorbent coating. This thesis presents the development of the first-ever real-time, video-rate, B-mode interventional OpUS imaging enabled by a newly developed Linearly-actuated Interventional Optical Ultrasound (LiOpUS) platform. Novel OpUS transmitter rapid-prototyping fabrication methods are presented, and a numerical framework was developed and used to optimise the OpUS source geometry. This was followed by benchtop studies including wire phantom imaging, demonstrating high resolution of 89 µm axially and 361 μm laterally. The probe was then successfully deployed in imaging intralumenal anatomical phantoms of the carotid arteries and the lungs, achieving high contrast images and image subsurface features mimicking lymph nodes. The project culminated in the successful in vivo imaging of the internal cardiovascular vessels of an adult porcine specimen, using a probe 1.8 mm in diameter, under x-ray image guidance. The probe demonstrated mechanical and manual resilience during the procedure and acquired high contrast images at clinically relevant frame rates of 8.5 Hz. Irradiation from the x-ray guidance showed no impact on the imaging quality, demonstrating the multimodal capacity of the materials used. The results demonstrate the clinical capacity of real-time optical ultrasound imaging in clinical workflows and present a significant advance in accelerating the development of interventional OpUS imaging devices.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Interventional cardiopulmonary optical ultrasound imaging via rapid actuation |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2024. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10201326 |
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