Iskander, Deena;
Roy, Noémi BA;
Payne, Elspeth;
Drasar, Emma;
Hennessy, Kelly;
Harrington, Yvonne;
Christodoulidou, Chrysi;
... De la Fuente, Josu; + view all
(2023)
Diamond-Blackfan anemia in adults: In pursuit of a common approach for a rare disease.
Blood Reviews
, 61
, Article 101097. 10.1016/j.blre.2023.101097.
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Abstract
Diamond-Blackfan anemia (DBA) is a rare bone marrow failure syndrome, usually caused by loss-of function variants in genes encoding ribosomal proteins. The hallmarks of DBA are anemia, congenital anomalies and cancer predisposition. Although DBA usually presents in childhood, the prevalence in later life is increasing due to an expanding repertoire of implicated genes, improvements in genetic diagnosis and increasing life expectancy. Adult patients uniquely suffer the manifestations of end-organ damage caused by the disease and its treatment, and transition to adulthood poses specific issues in disease management. To standardize and optimize care for this rare disease, in this review we provide updated guidance on the diagnosis and management of DBA, with a specific focus on older adolescents and adults. Recommendations are based upon published literature and our pooled clinical experience from three centres in the United Kingdom (U·K.). Uniquely we have also solicited and incorporated the views of affected families, represented by the independent patient organization, DBA U.K.
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