Verdi, Serena;
Rutherford, Saige;
Fraza, Charlotte;
Tosun, Duygu;
Altmann, Andre;
Raket, Lars Lau;
Schott, Jonathan M;
... Cole, James H; + view all
(2024)
Personalizing progressive changes to brain structure in Alzheimer's disease using normative modeling.
Alzheimer's & Dementia
, 20
(10)
pp. 6998-7012.
10.1002/alz.14174.
Preview |
Text
Alzheimer s Dementia - 2024 - Verdi - Personalizing progressive changes to brain structure in Alzheimer s disease using.pdf - Published Version Download (2MB) | Preview |
Abstract
INTRODUCTION: Neuroanatomical normative modeling captures individual variability in Alzheimer's disease (AD). Here we used normative modeling to track individuals’ disease progression in people with mild cognitive impairment (MCI) and patients with AD. METHODS: Cortical and subcortical normative models were generated using healthy controls (n ≈ 58k). These models were used to calculate regional z scores in 3233 T1-weighted magnetic resonance imaging time-series scans from 1181 participants. Regions with z scores < –1.96 were classified as outliers mapped on the brain and summarized by total outlier count (tOC). RESULTS: tOC increased in AD and in people with MCI who converted to AD and also correlated with multiple non-imaging markers. Moreover, a higher annual rate of change in tOC increased the risk of progression from MCI to AD. Brain outlier maps identified the hippocampus as having the highest rate of change. DISCUSSION: Individual patients’ atrophy rates can be tracked by using regional outlier maps and tOC. Highlights: Neuroanatomical normative modeling was applied to serial Alzheimer's disease (AD) magnetic resonance imaging (MRI) data for the first time. Deviation from the norm (outliers) of cortical thickness or brain volume was computed in 3233 scans. The number of brain-structure outliers increased over time in people with AD. Patterns of change in outliers varied markedly between individual patients with AD. People with mild cognitive impairment whose outliers increased over time had a higher risk of progression from AD.
| Type: | Article |
|---|---|
| Title: | Personalizing progressive changes to brain structure in Alzheimer's disease using normative modeling |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.14174 |
| Publisher version: | https://doi.org/10.1002/alz.14174 |
| Language: | English |
| Additional information: | Copyright © 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Alzheimer's disease, disease progression, longitudinal serial magnetic resonance imaging, mild cognitive impairment, neuroimaging, normative modeling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10201181 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
