Graham, Mackenzie;
Rossor, Martin;
Lawlor, Brian;
Naci, Lorina;
(2024)
Informing cognitively healthy research participants of modifiable dementia risk factors: Ethical implications.
Journal of Alzheimer's Disease
10.1177/13872877241292370.
(In press).
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Abstract
Research has shown that up to 40% of dementia incidence can be accounted for by 12 modifiable lifestyle risk factors. However, the predictive value of these risks factors at an individual level remains uncertain. Ethical considerations that are typically invoked with respect to the disclosure of individual research results-beneficence and non-maleficence, respect for autonomy, and justice-do not provide conclusive justification for, or against, disclosing modifiable risk factors for future dementia to cognitively unimpaired research participants. We argue for a different approach to evaluating the disclosure of individual-level modifiable risk factors for dementia. Rather than focusing on individual-level disease prediction and prevention, we suggest that disclosure should be evaluated based on the impact of behavioral and lifestyle changes on current brain health.
| Type: | Article |
|---|---|
| Title: | Informing cognitively healthy research participants of modifiable dementia risk factors: Ethical implications |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/13872877241292370 |
| Publisher version: | http://dx.doi.org/10.1177/13872877241292370 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Alzheimer's disease, brain health, dementia, modifiable, research ethics, research participants, risk factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10200913 |
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