Immune-Epithelial Cell Interactions in Lung Development, Homeostasis and Disease

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Immune-Epithelial Cell Interactions in Lung Development, Homeostasis and Disease

Yoshida, Masahiro; Arzili, Romina; Nikolić, Marko Z; (2024) Immune-Epithelial Cell Interactions in Lung Development, Homeostasis and Disease. The International Journal of Biochemistry & Cell Biology , Article 106703. 10.1016/j.biocel.2024.106703. (In press).

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Abstract

The importance of the crosstalk between lung epithelial and immune cells, which emerges from early development and lasts throughout life, is corroborated by a growing body of scientific evidence. This communication not only has a role in driving lung morphogenesis during development, but it is also required in adulthood for the maintenance of homeostasis and repair following infection or injury. Disruption of the intricate immune-epithelial crosstalk can lead to diseases such as COPD and IPF. In this review we summarise the current knowledge regarding the communication between various immune and epithelial cells in development, homeostasis, regeneration and disease, while identifying the current gaps in our knowledge required to facilitate the development of more effective therapies.

Type:	Article
Title:	Immune-Epithelial Cell Interactions in Lung Development, Homeostasis and Disease
Location:	Netherlands
DOI:	10.1016/j.biocel.2024.106703
Publisher version:	http://dx.doi.org/10.1016/j.biocel.2024.106703
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords:	Epithelium, Immune development, Immune-epithelial crosstalk, Lung epithelial development, Lung homeostasis and repair
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI:	https://discovery.ucl.ac.uk/id/eprint/10200884

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