Loi, Mauro;
Verheij, Marcel;
Nuyttens, Joost;
Scorsetti, Marta;
Livi, Lorenzo;
Hawkins, Maria A;
Huguet, Florence;
(2024)
From twilight to starlight? Debating the role of chemoradiotherapy in gastric cancer in the D2 dissection era.
La radiologia medica
, 129
(11)
pp. 1710-1719.
10.1007/s11547-024-01892-x.
![[thumbnail of Accepted Manuscript]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text (Accepted Manuscript)
Hawkins_Debating the role of chemoradiotherapy in gastric cancer in the D2 dissection era_AAM.pdf Access restricted to UCL open access staff until 2 October 2025. Download (147kB) |
|
Text (Supplementary Material)
Hawkins_Debating the role of chemoradiotherapy in gastric cancer in the D2 dissection era_SuppM.pdf Access restricted to UCL open access staff until 2 October 2025. Download (54kB) |
Abstract
Patients affected by resectable locally advanced gastric cancer (GC) should receive perioperative chemotherapy as a standard of care. However, an additional benefit of adjuvant chemoradiation (CRT) has been negated by modern trials in the era of extended surgical dissection, and CRT is currently only considered on an individual basis in case of suboptimal resection. However, the dismal prognosis of GC and the modest treatment completion rates of perioperative chemotherapy have pushed to reconsider CRT, particularly as a preoperative treatment, in light of modern treatment techniques, advances in the understanding of the immune landscape and development of targeted agents. The aim of this review is to critically assess the historical role of CRT, the limitations of current evidence and to debate its potential role in an integrated neoadjuvant strategy for patients with resectable GC.
| Type: | Article |
|---|---|
| Title: | From twilight to starlight? Debating the role of chemoradiotherapy in gastric cancer in the D2 dissection era |
| Location: | Italy |
| DOI: | 10.1007/s11547-024-01892-x |
| Publisher version: | http://dx.doi.org/10.1007/s11547-024-01892-x |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Gastric adenocarcinoma, Chemotherapy, Chemoradiation, Preoperative, Neoadjuvant |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10200759 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
